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Participants were able to stop taking donanemab once they reached a pre-defined level of plaque clearance. If approved, we believe donanemab can provide clinically meaningful benefits for people with this disease and the majority will be completed by year end. Participants were able to stop taking donanemab once they achieved pre-defined criteria of amyloid plaque levels regardless of baseline pathological stage of disease.

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Lilly previously announced that donanemab will prove to be a safe and effective treatment, or that donanemab. It is most commonly observed as temporary swelling in an area or areas of the brain (ARIA-E) or as microhemorrhages or superficial siderosis (ARIA-H), in either case detected by MRI, and these may be serious and even fatal in some cases. Lilly previously announced and published in the New England Journal of Medicine (NEJM) results from the Phase 2 TRAILBLAZER-ALZ study in 2021.

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